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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

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Articles 11 Documents

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Search results for , issue "Vol 15, No 2 (2020)" : 11 Documents clear

Backmatter (Instruction for author and back cover) Amin Fatoni
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Backmatter (Instruction for author and back cover) of the print version

Anti-toxicity test of Peperomia pellucida steeping on liver function in diabetic-induced rat Saryono Saryono; Hernayanti Hernayanti; Atikah Proverawati
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Liver is important for both defense mechanism and protein synthesis in the human body. This study examined the anti-toxicity of Peperomia pellucida on liver function of diabetic-induced rats. It was an experimental study using pre- and post-test control group design. Rats were categorized into five groups, i.e., groups of healthy control (A), negative control (B), and treatment (C-E) with dosages of 150, 300, and 600 mg/kg of P. pellucida, respectively. Each group comprises of 5 rats. The TNF-a, IL-12, and GSH were measured before and after a 14 days administration of P. pellucida. The data were analyzed by using one-way ANOVA test followed by Duncan's post hoc test with a significance level of 5%. The result showed that P. pellucida steeping can improve liver cell damage, which was shown from the parameters of liver function, inflammation, and antioxidants. The mean of TNF-a and IL-12 levels decreased while the total protein, albumin, and GSH levels increased significantly after administration of P. pellucida steeping. Our study concluded that P. pellucida steeping might reduce TNF-a and IL-12 levels, and increased GSH level in diabetic-induced rat. A 300 mg/kg was the most effective dosage to reduce IL-12 and increase GSH.

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) Amin Fatoni
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Frontmatter (Front Cover, Editorial Team, Preface and Table of Contents) of the print version

Removal of Cu Metals from Wastewater by Adsorption using Synthetic Zeolites from Rice Husk and Corncob Imas Solihat; Lilis Sulistiawaty; Putri Hawa Syaifie; Agus Taufiq
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Heavy metals, such as Cu, are hazardous components so that it needs to reduce their concentration due to their negative impact on the environment. One method that can be used to reduce heavy metals in waste is to use adsorbents (synthetic zeolites). Utilization of agricultural waste such as rice husks and corncobs as precursors of synthetic zeolites will add economic value because it is relatively cheap with a lot of availability. This research aimed to find out new variants of synthetic zeolites, which can reduce the concentration of Cu in the adsorption process. The study consisted of 3 stages, the first stage was zeolite synthesis by the sol-gel method with 3 zeolite variants (A, B and C), the second stage was characterization using XRD and SEM, and the third stage was zeolites optimization (variations in pH, weight, and concentration). According to the results of SEM, zeolite B had a larger and uniform pore size so as it produced a greater adsorption capacity (4.82 mg/g) to be compared with zeolites A and C. The results showed synthetic zeolite C was able to adsorb Cu waste by following the adsorption isotherm model of Langmuir

Kinetics and Thermodynamics Studies of Copper(II) Adsorption onto Activated Carbon Prepared from Salacca zalacca Peel Dewi Yuanita Lestari; Endang Widjajanti Laksono
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Highly porous and stable materials, such as alumina, silica, carbon, zeolite, and bentonite, are well known and have been used as metal ion adsorbents. However, the use of biogenic carbon as adsorbent is relatively rare. The adsorption of copper(II) onto activated carbon extracted from Salcaca zalacca peel was studied. The effect of initial copper concentration, contact time, and a series temperature was studied. Adsorption was carried out in a batch technique. The adsorption equilibrium was reached after 60 minutes of contact time. The adsorption data had a better fitting line for the Langmuir isotherm model. The Langergren and also Ho and Mc Kay equations were used to predict the adsorption kinetics. The adsorption process obeyed a second-order kinetics model. The Thermodynamic parameters were ∆H°= -42.4180 kJ/mol; ∆S°= -0.0843 kJ/mol; ∆G°<0. These values indicated that the adsorption was exothermic and spontaneous. The low ∆G° value revealed that the main mechanism controlling the adsorption process was physisorption.

DFT Study of Leuco-Indigo and Indigo as Active Material in Dye-Sensitized Solar Cell Maahury, Mirella Fonda; Male, Yusthinus Thobias; Martoprawiro, Muhamad Abdulkadir
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Computational study of natural indigo has been carried out to get the optimized structure and electronic properties of two indigo at different pH.Â It has been found that indigo has the potential to be applied asÂ active material in the dye-sensitized solar cell. Computational calculations are performed using Density Functional Theory (DFT) with B3LYP functional and 6-31G(d,p) for ground state geometry optimization and Time Dependent-Density Functional Theory (TD-DFT) for excited states single point calculation. All calculations are carried out in the gas phase. Geometry optimization results show that Indigo has a planar structure, whereas leuco-indigo structure is not planar. Leuco-indigo absorption wavelength is shorter than indigo. The density of HOMO and LUMO is spreading throughout the molecule. The density of electrons at LUMO extends to the anchoring group. Based on excitation energy, absorption wavelength, excitation composition, and HOMO-LUMO density, it can be concluded that indigoÂ has the potential to be applied inÂ dye-sensitized solar cell (DSSC)

Phytochemical Analysis and Antioxidant Activity of Brotowali (Tinospora crispa L. Mier) Stem Warsinah, Warsinah; Baroroh, Hanif Nasiatul; Harwoko, Harwoko
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Free radical in the body could cause degenerative diseases such as diabetes mellitus and hyperlipidemia, which could be prevented by the supplementation of antioxidant whether it is synthetic or natural. Flavanoids is a phenolic compound, was extracted from natural sources is known for its antioxidative potential. This research aimed to investigate the active compounds in brotowali (Tinospora crispa) stem to find new antioxidative potential using its ability to bindÂ 2, 2â€™-diphenyl-1-picrylhydrazylÂ (DPPH). Brotowali stem was extracted using ethanol and fractioned usingÂ n-hexane, ethyl acetate, and water. Water fraction was hydrolyzed by chloric acid. The antioxidant activity of ethanol extract, water fraction, and hydrolized water fraction (subfraction I and subfraction II) were determined using spectrophotometry (DPPH methods). The compound of flavonoid was identified using KLT with AlCl3Â reagent spray. TheÂ results showed that ethanol extract andÂ water fraction of brotowali stemÂ contained flavonoid glycoside of flavonol group. Antioxidant activity, quantified using IC50, of ethanol extract, water fraction, subfraction I and subfractiont II were 49.92Î¼g/mL, 38.25Â Î¼g/mL, 36.12Â Î¼g/mL, and 16.18Â Î¼g/mL, respectively. In addition, this research was found that hydrolysis of water fraction using chloric acid like in subfraction I and subfraction II was able to improve its antioxidant activity.

Analysis of Solid-State Interactions of Ketoprofen-Coformer Binary Mixtures by DSC and Hot Stage Microscopy Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Ketoprofen is a non-steroidal anti-inflammatory drug with poor water solubility, so the absorption is less than optimal. One method to improve the solubility of ketoprofen is through the formation of multicomponent solid forms. The success of the formation of the multicomponent solid forms is strongly influenced by interactions between components in their solids. In this study, the analysis of the interactions in solid form of ketoprofen-coformers was carried out using the differential scanning calorimetry (DSC) and hot stage microscopy (HSM) with adipic acid and isonicotinamide as coformers. From the experimental results, the mixtures of ketoprofen-adipic acid show a solid-liquid phase diagram that indicates a simple eutectic system with eutectic points on the molar fraction of ketoprofen 0.9 and temperature at 92.9 °C. The ketoprofen-isonicotinamide mixtures have a eutectic system with the peritectic point. The solid-liquid phase diagram has indicated that the ketoprofen-adipic acid in eutectic composition forms a miscible liquid phase without interaction in its solid form, whereas the ketoprofen-isonicotinamide forms a miscible liquid phase accompanied by interaction with the excess component. The results of the HSM analysis showed the same phenomenon as the result of the DSC experiment and have confirmed with the FTIR analysis

Characterization of Curcuminoid from Curcuma xanthorrhiza and Its Activity Test as Antioxidant and Antibacterial Sri Atun; Nurfina Aznam; Retno Arianingrum; Senam Senam; Bian Ihda An Naila; Astuti Lestari; Nur Aini Purnamaningsih
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

Curcuminoids are the main component found in many Zingiberaceae family plants. The aim of this study was to characterize curcuminoid and its activity test as an antioxidant and antibacterial. Dryed powder of C. xanthorrhiza (1 kg) was macerated with ethanol for 24 hours at room temperature. Ethanol extract of C. xanthorrhiza was subsequently fractionated with n-hexane and chloroform to take the yellow or orange indicated contain of curcuminoids. Analysis of total phenolic levels was carried out by the Follin-Ciaocalteau method. The isolation of curcuminoid componens from this fraction was carried out by chromatographic method and the structure elucidation was performed by interpretation of spectroscopic data, including UV, IR, 1H and 13C NMR 1D and 2D. The antioxidant activity test used the DPPH (2,2-diphenylpicrylhydrazyl) method, while the antibacterial activity test used Kirby Bauer test diffusion method. The results showed that the curcuminoid fraction yield was 10.06% from ethanol extract C. xanthorrhiza. The total phenolic content of curcuminoids fraction was 745.45 ± 18.5 mg galic acid (GA)/g extract. Curcuminoids fraction was isolated a known compound desmethoxycurcumin (1). The content of demethoxycurcumin (1) in curcuminoid fraction is 20.97 %.The antioxidant activity of curcuminoids fraction showed strongest activity with IC50 24.98 µg/ml. Antibacterial activity against of the four pathogenic bacteria showed medium activity. The study suggests that curcuminoids extract from C. xanthorrhiza rhizome have potential compounds could be suitable for antioxidant and the treatment of various infections caused of microbial.

Removal of Pb(II) using Hydroxyapatite from Golden Snail Shell (Pomacea canaliculata L.) Modified with Silica Poedji Loekitowati Hariani; Fahma Riyanti; Fatma Fatma; Addy Rachmat; Aldi Herbanu
Molekul Vol 15, No 2 (2020)
Publisher : Universitas Jenderal Soedirman

The composites of hydroxyapatite and SiO2 were successfully synthesized. The hydroxyapatite was prepared from golden snail shells (Pomacea canaliculata L). The hydroxyapatite and hydroxyapatite-SiO2 composites were characterized using XRD, FTIR, SEM-EDS. Furthermore, hydroxyapatite and hydroxyapatite-SiO2 composites were used to remove Pb(II) from aqueous solution. Various adsorption parameters such as pH of the solution, contact time, and initial Pb(II) concentration were used to study the adsorption process. The optimum pH of the solution for removal of Pb(II) by hydroxyapatite and hydroxyapatite-SiO2 composite at pH 6 and contact time at 60 minutes. Both adsorbents follow the Langmuir isotherm. The maximum adsorption capacity of the hydroxyapatite-SiO2 composite is greater compare to hydroxyapatite, respectively 135.14 and 123.46 mg/g. The pseudo-second order kinetic model had a correlation coefficient (R2) greater than the pseudo-first order so pseudo-second order kinetic is better to describe adsorption kinetics

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Amin Fatoni

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Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

Phone -

Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA